To do that, a lot of interval work is necessary-a kind of training that doesn't seem as relevant for soccer. Running for conditioning, as soccer players do (and I've always had much respect for their commitment to high levels of conditioning, which are probably higher than any other sport other than XC), won't get you under 4:30. You can't just go out and run (say) 4:28, without specifically training to do that.
I was a XC runner in HS and college, not a soccer player, so I understand what it takes to go under 4:30, even today when lots of HS runners can go under 4:20. I agree with the comment above that any soccer player who can break 4:30 ought to be running XC. Many players have said that they almost never play a team with comparable fitness-and they are in the best position to make such a comparison.
I don't claim that the Falcons are the fittest team in D3, but surely they are among the fittest teams, despite the fact that their liberal substitution practice would suggest otherwise. As far as I know, just one player managed to go a little under 4:40, namely, the AA defender and POY, J D Binger. Under Brandt it was 1 mile in 5 minutes, which most players reached. Twenty years ago under Layton Shoemaker, Messiah had a standard of 2 miles in 12 minutes. Forgive my skepticism, but I'd like to see some evidence that any college use a 4:30 mile as a standard in soccer.